Journal article

Plasmodium strain determines dendritic cell function essential for survival from malaria

Michelle N Wykes, Xue Q Liu, Lynette Beattie, Danielle I Stanisic, Katryn J Stacey, Mark J Smyth, Ranjeny Thomas, Michael F Good

PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2007

Abstract

The severity of malaria can range from asymptomatic to lethal infections involving severe anaemia and cerebral disease. However, the molecular and cellular factors responsible for these differences in disease severity are poorly understood. Identifying the factors that mediate virulence will contribute to developing antiparasitic immune responses. Since immunity is initiated by dendritic cells (DCs), we compared their phenotype and function following infection with either a nonlethal or lethal strain of the rodent parasite, Plasmodium yoelii, to identify their contribution to disease severity. DCs from nonlethal infections were fully functional and capable of secreting cytokines and stimulat..

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University of Melbourne Researchers