Compartment-Specific Remodeling of Splenic Micro-Architecture during Experimental Visceral Leishmaniasis
Pinar Yurdakul, Jane Dalton, Lynette Beattie, Nlajmeeyah Brown, Sibel Erguven, Asher Maroof, Paul M Kaye
The American Journal of Pathology | ELSEVIER SCIENCE INC | Published : 2011
Progressive splenomegaly is a hallmark of visceral leishmaniasis in humans, canids, and rodents. In experimental murine visceral leishmaniasis, splenomegaly is accompanied by pronounced changes in microarchitecture, including expansion of the red pulp vascular system, neovascularization of the white pulp, and remodeling of the stromal cell populations that define the B-cell and T-cell compartments. Here, we show that Ly6C/G(+) (Gr-1(+)) cells, including neutrophils and inflammatory monocytes, accumulate in the splenic red pulp during infection. Cell depletion using monoclonal antibody against either Ly6C/G(+) (Gr-1; RB6) or Ly6G(+) (1A8) cells increased parasite burden. In contrast, depletio..View full abstract
Awarded by Scientific and Technological Research Council of Turkey
Awarded by Medical Research Council
Supported by grants from the Wellcome Trust and the Medical Research Council (P.M.K.). Supported also in part by the Overseas Research Fellowship Program (2214) of the Scientific and Technological Research Council of Turkey.