Posttranscriptional regulation of Il10 gene expression allows natural killer cells to express immunoregulatory function
Asher Maroof, Lynette Beattie, Soombul Zubairi, Mattias Svensson, Simona Stager, Paul M Kaye
Immunity | CELL PRESS | Published : 2008
Natural killer (NK) cells play a well-recognized role in early pathogen containment and in shaping acquired cell-mediated immunity. However, indirect evidence in humans and experimental models has suggested that NK cells also play negative regulatory roles during chronic disease. To formally test this hypothesis, we employed a well-defined experimental model of visceral leishmaniasis. Our data demonstrated that NKp46(+)CD49b(+)CD3(-) NK cells were recruited to the spleen and into hepatic granulomas, where they inhibited host protective immunity in an interleukin-10 (IL-10)-dependent manner. Although IL-10 mRNA could be detected in activated NK cells 24 hr after infection, the inhibitory func..View full abstract
Awarded by Medical Research Council
The authors thank the staff of the LSHTM and University of York Biological Services Facilities for animal husbandry, staff of the Biology Department Technology Facility for assistance with flow cytometry and imaging, J. Langhorne, A. O'Garra, and D. Kioussis for generously providing mice, and M. Coles and M. Kullberg for critical review of the manuscript. This work was supported by grants from The Wellcome Trust and the U.K. Medical Research Council.