Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: A multinational prospective longitudinal cohort study

Y Shehabi; R Bellomo; S Kadiman; LK Ti; B Howe; MC Reade; TM Khoo; A Alias; YL Wong; A Mukhopadhyay; C McArthur; I Seppelt; SA Webb; M Green; MJ Bailey; E Ibrom; C Maher; C Mashonganyika; H McKee; V Bennett; DJ Cooper; S Vallance; G Eastwood; L Peck; H Young; S Eliott; I Mercer; J Sidhu; A Whitfield; G Ding; P Hatfield; K Smith; T Coles; J Dennett; T Summers; A Ruther; R Anderson; E Jones; D Milliss; H Wong; J Botha; S Allsop; M Kanhere; J Wood; C Hogan; J Tai; T Williams; A Buckley; P Garrett; S McDonald; C Cuzner; L Weisbrodt; F Bass; P Edhouse; M Sana; J Chamberlain; A Bicknell; B Roberts; E Casey; A Cheng; D Inskip; J Myburgh; J Holmes; J Santamaria; R Smith; P Nair; C Reynolds; B Johnson; M Sterba; KK Wong; S Venugopal; V Rai; M Shahnaz; V Ramoo; S Jose; O Ozturk; SNZ Ramlee; BS Foon; R Amran; RKA Narula; ES Md Ramly; KA Hapiz; L I-Liang; MHC Morad; MN Ali; HN Raihan; SI Azizum; Y Suzana; H Haryati; SS Zawati; JN Ismeev; MA Zulkarnain; M Omar; SA Omar; SR Ismail; N Hassan; Z Zakaria; S Mohtar; M Ahmad; W Suai

Journal article

Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: A multinational prospective longitudinal cohort study

Y Shehabi, R Bellomo, S Kadiman, LK Ti, B Howe, MC Reade, TM Khoo, A Alias, YL Wong, A Mukhopadhyay, C McArthur, I Seppelt, SA Webb, M Green, MJ Bailey, E Ibrom, C Maher, C Mashonganyika, H McKee, V Bennett Show all

Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

DOI: 10.1097/CCM.0000000000003071

Abstract

Objectives: In the absence of a universal definition of light or deep sedation, the level of sedation that conveys favorable outcomes is unknown. We quantified the relationship between escalating intensity of sedation in the first 48 hours of mechanical ventilation and 180-day survival, time to extubation, and delirium. Design: Harmonized data from prospective multicenter international longitudinal cohort studies Setting: Diverse mix of ICUs. Patients: Critically ill patients expected to be ventilated for longer than 24 hours. Interventions: Richmond Agitation Sedation Scale and pain were assessed every 4 hours. Delirium and mobilization were assessed daily using the Confusion Assessment Met..

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University of Melbourne Researchers

Michael Reade Author

Glenn Eastwood Author

Grants

Funding Acknowledgements

The parent SPICE studies were supported by an unrestricted research grant from Pfizer (Hospira, Lake forest, IL), Grant-in-Aide Program.Dr. Shehabi declares unrestricted research and educational grant support from Pfizer (Hospira, Lake Forest, IL), Orion Pharma - Helsinki Finland in support of the Sedation Practice in Intensive Care Evaluation Program. Dr. Reade declares unrestricted research and educational grant support from Pfizer (Hospira, Melbourne, VIC) Australia. Dr. McArthur disclosed project grant funding from the Health Research Council of New Zealand for a prospective, randomized clinical trial of intensive care sedation. The remaining authors have disclosed that they do not have any potential conflicts of interest.