Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Sophie Paquet-Fifield; Shir Lin Koh; Lesley Cheng; Laura M Beyit; Carolyn Shembrey; Christina Molck; Corina Behrenbruch; Marina Papin; Meritxell Gironella; Sophie Guelfi; Ramona Nasr; Fanny Grillet; Michel Prudhomme; Jean-Francois Bourgaux; Antoni Castells; Jean-Marc Pascussi; Alexander G Heriot; Alain Puisieux; Melissa J Davis; Julie Pannequin; Andrew F Hill; Erica K Sloan; Frederic Hollande

Journal article

Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Sophie Paquet-Fifield, Shir Lin Koh, Lesley Cheng, Laura M Beyit, Carolyn Shembrey, Christina Molck, Corina Behrenbruch, Marina Papin, Meritxell Gironella, Sophie Guelfi, Ramona Nasr, Fanny Grillet, Michel Prudhomme, Jean-Francois Bourgaux, Antoni Castells, Jean-Marc Pascussi, Alexander G Heriot, Alain Puisieux, Melissa J Davis, Julie Pannequin Show all

Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2018

DOI: 10.1158/0008-5472.CAN-17-1869

University of Melbourne Researchers

Sophie Paquet-Fifield Author Microbiology and Immunology

Sandy Heriot Author Surgery - St Vincent's Hospital

Frederic Hollande Author Clinical Pathology

Melissa Davis Author Medical Biology (W.E.H.I.)

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ESTABLISHING AND VALIDATING A NEW THERPAUETIC TARGET FOR COLON AND STOMACH CANCER

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by French Association pour la Recherche contre le Cancer (ARC)

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (#1049561, #1069024) and the French Association pour la Recherche contre le Cancer (ARC)(#5046).The authors wish to thank Drs. Hyun-Jung Cho and Paul McMillan (BOMP imaging facility, University of Melbourne) and Dr. Vanta Jameson (Flow Cytometry facility, University of Melbourne) for their technical support. They are also very grateful to Prof. K. Harvey for helpful discussions and for sharing Hippo/YAP pathway reagents. Biospecimens and data used for TMA immunostaining experiments were obtained from the Victorian Cancer Biobank, Victoria, Australia, with appropriate ethics approval. The Victorian Cancer Biobank is supported by the Victorian Government.