Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Sophie Paquet-Fifield; Shir Lin Koh; Lesley Cheng; Laura M Beyit; Carolyn Shembrey; Christina Molck; Corina Behrenbruch; Marina Papin; Meritxell Gironella; Sophie Guelfi; Ramona Nasr; Fanny Grillet; Michel Prudhomme; Jean-Francois Bourgaux; Antoni Castells; Jean-Marc Pascussi; Alexander G Heriot; Alain Puisieux; Melissa J Davis; Julie Pannequin; Andrew F Hill; Erica K Sloan; Frederic Hollande

Journal article

Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Sophie Paquet-Fifield, Shir Lin Koh, Lesley Cheng, Laura M Beyit, Carolyn Shembrey, Christina Molck, Corina Behrenbruch, Marina Papin, Meritxell Gironella, Sophie Guelfi, Ramona Nasr, Fanny Grillet, Michel Prudhomme, Jean-Francois Bourgaux, Antoni Castells, Jean-Marc Pascussi, Alexander G Heriot, Alain Puisieux, Melissa J Davis, Julie Pannequin Show all

Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2018

DOI: 10.1158/0008-5472.CAN-17-1869

University of Melbourne Researchers

Sophie Paquet-Fifield Author Microbiology and Immunology

Sandy Heriot Author Surgery - St Vincent's Hospital

Fred Hollande Author Clinical Pathology

Melissa Davis Author Biochemistry and Molecular Biology

Related Projects (2)

Elucidating The Role Of Claudin-2 In Tumour Initiation And Metastasis Development From Colorectal Cancer: Consequence For Tumour Relapse

Mortality from colorectal cancer is often due to the development of metastases. Cancer stem cells (CSC) are suspected to provide a major dri..

Establishing And Validating A New Therpauetic Target For Colon And Stomach Cancer

Cancers of the stomach and the colon are a major health burden. One of the central signaling molecules that drives these cancers is called S..

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by French Association pour la Recherche contre le Cancer (ARC)

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (#1049561, #1069024) and the French Association pour la Recherche contre le Cancer (ARC)(#5046).The authors wish to thank Drs. Hyun-Jung Cho and Paul McMillan (BOMP imaging facility, University of Melbourne) and Dr. Vanta Jameson (Flow Cytometry facility, University of Melbourne) for their technical support. They are also very grateful to Prof. K. Harvey for helpful discussions and for sharing Hippo/YAP pathway reagents. Biospecimens and data used for TMA immunostaining experiments were obtained from the Victorian Cancer Biobank, Victoria, Australia, with appropriate ethics approval. The Victorian Cancer Biobank is supported by the Victorian Government.