Journal article

Signatures of competition and strain structure within the major blood-stage antigen of Plasmodium falciparum in a local community in Ghana

Mary M Rorick, Yael Artzy-Randrup, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Thomas S Rask, Abraham Oduro, Anita Ghansah, Kwadwo Koram, Karen P Day, Mercedes Pascual

ECOLOGY AND EVOLUTION | WILEY | Published : 2018

Abstract

The concept of niche partitioning has received considerable theoretical attention at the interface of ecology and evolution of infectious diseases. Strain theory postulates that pathogen populations can be structured into distinct nonoverlapping strains by frequency-dependent selection in response to intraspecific competition for host immune space. The malaria parasite Plasmodium falciparum presents an opportunity to investigate this phenomenon in nature, under conditions of high recombination rate and extensive antigenic diversity. The parasite's major blood-stage antigen, PfEMP1, is encoded by the hyperdiverse var genes. With a dataset that includes thousands of var DBLα sequence types sam..

View full abstract

Grants

Awarded by Fogarty International Center at National Institutes of Health Program on the Ecology and Evolution of Infectious Diseases (EEID)


Awarded by National Institute of Allergy and Infectious Disease, National Institutes of Health


Awarded by FOGARTY INTERNATIONAL CENTER


Funding Acknowledgements

Fogarty International Center at National Institutes of Health Program on the Ecology and Evolution of Infectious Diseases (EEID) [Grant number: R01-TW009670]; and the National Institute of Allergy and Infectious Disease, National Institutes of Health [Grant number: R01-AI084156].