Journal article

Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke

Jakob Hakon, Miriana Jlenia Quattromani, Carin Sjolund, Gregor Tomasevic, Leeanne Carey, Jin-Moo Lee, Karsten Ruscher, Tadeusz Wieloch, Adam Q Bauer

NEUROIMAGE-CLINICAL | ELSEVIER SCI LTD | Published : 2018

Abstract

Stroke causes direct structural damage to local brain networks and indirect functional damage to distant brain regions. Neuroplasticity after stroke involves molecular changes within perilesional tissue that can be influenced by regions functionally connected to the site of injury. Spontaneous functional recovery can be enhanced by rehabilitative strategies, which provides experience-driven cell signaling in the brain that enhances plasticity. Functional neuroimaging in humans and rodents has shown that spontaneous recovery of sensorimotor function after stroke is associated with changes in resting-state functional connectivity (RS-FC) within and across brain networks. At the molecular level..

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Grants

Awarded by NIH


Awarded by Swedish Research Council


Awarded by Hans-Gabriel and Alice Trolle-Wachtmeister Foundation


Awarded by Strategic Research Area MultiPark


Awarded by Pia Stahl Foundation


Awarded by Royal Physiographic Society of Lund


Awarded by STROKE Riksforbundet


Awarded by James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award


Awarded by NHMRC


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

The authors want to thank Kerstin Beirup for outstanding technical assistance. This work was supported by NIH grant 5K25NS08375404 (AQB), the Swedish Research Council (TW 2011-2652 and 2014-3802), the Hans-Gabriel and Alice Trolle-Wachtmeister Foundation (TW 126360), Alborada Trust (TW), the Strategic Research Area MultiPark (TW 128000), the Pia Stahl Foundation (TW 31434731240), the Royal Physiographic Society of Lund (JH, TW and MJQ 110312), and the STROKE Riksforbundet (MJQ 110316), James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award (# 220020413) and NHMRC grants (1022694; 1077898) (LC).