Journal article
Genome-wide average DNA methylation is determined in utero
Shuai Li, Ee Ming Wong, Pierre-Antoine Dugue, Allan F McRae, Eunae Kim, Ji-Hoon Eric Joo, Tuong L Nguyen, Jennifer Stone, Gillian S Dite, Nicola J Armstrong, Karen A Mather, Anbupalam Thalamuthu, Margaret J Wright, David Ames, Roger L Milne, Jeffrey M Craig, Richard Saffery, Grant W Montgomery, Yun-Mi Song, Joohon Sung Show all
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS | Published : 2018
DOI: 10.1093/ije/dyy028
Abstract
BACKGROUND: Investigating the genetic and environmental causes of variation in genome-wide average DNA methylation (GWAM), a global methylation measure from the HumanMethylation450 array, might give a better understanding of genetic and environmental influences on methylation. METHODS: We measured GWAM for 2299 individuals aged 0 to 90 years from seven twin and/or family studies. We estimated familial correlations, modelled correlations with cohabitation history and fitted variance components models for GWAM. RESULTS: The correlation in GWAM for twin pairs was ∼0.8 at birth, decreased with age during adolescence and was constant at ∼0.4 throughout adulthood, with no evidence that twin pair c..
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Grants
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by Bonnie Babes Foundation
Awarded by Financial Markets Foundation for Children
Awarded by NHMRC
Awarded by Research of Korea Centers for Disease Control, and Prevention
Awarded by National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning
Awarded by Centre for Research Excellence Grant from the NHMRC
Awarded by National Breast Cancer Foundation
Awarded by Wellcome Trust
Awarded by Centre of Research Excellence Grant from the NHMRC
Awarded by NHMRC/Australian Research Council Strategic Award
Funding Acknowledgements
Data from some studies were obtained from public data repositories. However, we would like to acknowledge the funding for all studies. The PETS was supported by grants from the Australian National Health and Medical Research Council (NHMRC) (grant numbers 437015 and 607358 to J.C. and R.S.), the Bonnie Babes Foundation (grant number BBF20704 to J.M.C.), the Financial Markets Foundation for Children (grant number 032-2007 to J.M.C.) and by the Victorian Government's Operational Infrastructure Support Program. The BSGS was supported by NHMRC grants 1010374, 496667 and 1046880. The KHTS was supported by a fund (2014-E71004-00) by Research of Korea Centers for Disease Control, and Prevention and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (grant number NRF2017R1A2B2002136). The AMDTSS was facilitated through the Australian Twin Registry, a national research resource in part supported by a Centre for Research Excellence Grant from the NHMRC (grant number 1079102). The AMDTSS was supported by NHMRC (grant numbers 1050561 and 1079102), Cancer Australia and National Breast Cancer Foundation (grant number 509307). The MuTHER was funded by a programme grant from the Wellcome Trust (081917/Z/07/Z), and receives support from the National Institute for Health Research BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. The OATS was facilitated through the Australian Twin Registry, a national research resource in part supported by a Centre of Research Excellence Grant from the NHMRC (grant number 1079102). OATS was funded by the NHMRC/Australian Research Council Strategic Award Grant 401162 and the NHMRC Project Grants 1045325 and 613608. The MCCS was made possible thanks to the funding obtained from the NHMRC (including project grant numbers 1011618, 1026892, 1026522, 1050198, 623206 and 1043616, and program grant numbers 209057 and 1074383).S.L. is supported by the Australian Postgraduate Award (international), International Postgraduate Research Scholarship and the Richard Lowell Travelling Scholarship from the University of Melbourne. T.L.N. is supported by an NHMRC Post-Graduate Scholarship and the Richard Lowell Travelling Scholarship from the University of Melbourne. J.L.H. is a Senior Principal Research Fellow of NHMRC and a Distinguished Visiting Professor at Seoul National University. A.F.M. and G.W.M. are supported by the NHMRC Fellowship Scheme (1083656 and 1078399).