Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania

O Dandash; M Yücel; R Daglas; C Pantelis; P McGorry; M Berk; A Fornito

Journal article

Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania

O Dandash, M Yücel, R Daglas, C Pantelis, P McGorry, M Berk, A Fornito

Translational Psychiatry | SPRINGERNATURE | Published : 2018

DOI: 10.1038/s41398-018-0108-8

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Abstract

Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and quetiapine are effective treatments for mania but their neurobiological effects remain largely unknown. We conducted a single-blinded randomized controlled maintenance trial in 61 FEM patients and 30 healthy controls. Patients were stabilized for a minimum of 2 weeks on lithium plus quetiapine then randomly assigned to either lithium (serum level 0.6 mmol/L) or quetiapine (dosed up to 800 mg/day) treatment for 12 months. Resting-state fMRI was acquired at baseline, 3 months (patient only) and 12 months. The effects of treatment group, time and their interaction, on..

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University of Melbourne Researchers

Orwa Dandash Author

Christos Pantelis Author

Patrick McGorry Author

Michael Berk Author

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Awarded by AstraZeneca

Funding Acknowledgements

This study was supported by an unrestricted grant from Astra Zeneca. The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. MB was supported by a NHMRC Senior Principal Research Fellowship 1059660. C.P. was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386 & 1105825). P.M. was supported by a NHMRC SPR fellowship. A.F. was supported by the Australian Research Council (ID: FT130100589) and NHMRC (ID: 1050504). M.Y. was supported by a National Health and Medical Research Council Fellowship (ID: 1117188) and the David Winston Turner Endowment Fund.