Distinguishing cell shoving mechanisms
Pingyu Nan, Darragh M Walsh, Kerry A Landman, Barry D Hughes
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018
Motivated by in vitro time-lapse images of ovarian cancer spheroids inducing mesothelial cell clearance, the traditional agent-based model of cell migration, based on simple volume exclusion, was extended to include the possibility that a cell seeking to move into an occupied location may push the resident cell, and any cells neighbouring it, out of the way to occupy that location. In traditional discrete models of motile cells with volume exclusion such a move would be aborted. We introduce a new shoving mechanism which allows cells to choose the direction to shove cells that expends the least amount of shoving effort (to account for the likely resistance of cells to being pushed). We call ..View full abstract
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Awarded by Australian Research Council's Discovery scheme
Awarded by Australian Research Council Discovery Project
This work was funded by the Australian Research Council's Discovery scheme (grant number: DP140100339, awarded to BDH and KAL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This research was supported by an Australian Research Council Discovery Project (DP140100339).