Journal article
Serum IGFBP-2 levels are associated with reduced insulin sensitivity in obese children
SW Yau, BE Harcourt, KT Kao, EJ Alexander, VC Russo, GA Werther, MA Sabin
Clinical Obesity | WILEY | Published : 2018
DOI: 10.1111/cob.12245
Abstract
Insulin-like growth factor binding protein 2 (IGFBP-2) may represent a critical link between body composition and insulin sensitivity. We investigated the relationship between circulating IGFBP-2 levels, body composition, insulin sensitivity, energy intake and physical activity in children with obesity. Children were recruited via the Weight Management Service at the Royal Children's Hospital, Melbourne, as part of the Childhood Overweight BioRepository of Australia (COBRA). Comprehensive anthropometric, biochemical and environmental data were collected and compared to serum IGFBP-2 levels (measured by enzyme-linked immunosorbent assay). Multiple regression modelling was used to assess the i..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
We are grateful for the contribution of COBRA cohort participants. Funding for this study was from the Murdoch Children's Research Institute. Authors from the Murdoch Children's Research Institute are supported in part by the State Government of Victoria Operational Infrastructure Support Program. MAS and BEH were supported by the National Health and Medical Research Council, Professional Training Fellowship (MAS: APP1012201) and Peter Doherty Early Career Fellowship (BEH: APP1072086). SWY was supported by an Australian Postgraduate Award scholarship.