Journal article

Cardiac Index Changes With Fluid Bolus Therapy in Children With SepsisAn Observational Study

Elliot Long, Franz E Babl, Ed Oakley, Bennett Sheridan, Trevor Duke



OBJECTIVES: Fluid bolus therapy is the initial recommended treatment for acute circulatory failure in sepsis, yet it is unknown whether this has the intended effect of increasing cardiac index. We aimed to describe the effect of fluid bolus therapy on cardiac index in children with sepsis. DESIGN: A prospective observational cohort study. SETTING: The Emergency Department of The Royal Children's Hospital, Melbourne, VIC, Australia. PATIENTS: A convenience sample of children meeting international consensus criteria for sepsis with acute circulatory failure. INTERVENTION: Treating clinician decision to administer fluid bolus therapy. MEASUREMENTS AND MAIN RESULTS: Transthoracic echocardiograph..

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Awarded by National Health and Medical Research Council Centre of Research Excellence Grant for Pediatric Emergency Medicine, Canberra, ACT, Australia

Funding Acknowledgements

Supported, in part, by a Windermere Foundation Doctoral Scholarship in Health, a National Health and Medical Research Council Centre of Research Excellence Grant for Pediatric Emergency Medicine (GNT1058560), Canberra, ACT, Australia, the Victorian Governments Infrastructure Support Program, Melbourne, VIC, Australia, a Shields Research Entry Scholarship provided by the Royal Australasian College of Physicians, Sydney, NSW, Australia, and a Clinical Sciences Theme Grant provided by The Royal Children's Hospital Foundation, Melbourne, VIC, Australia.Dr. Babl's institution received funding from the National Health and Medical Research Council (NHMRC) Centres of Research Excellence grant and NHMRC Practitioner Fellowship. He was supported by a Melbourne Children's Clinician Scientist Fellowship, Melbourne, VIC, Australia, and an NHMRC Practitioner Fellowship. Dr. Sheridan received funding from the Extracorporeal Life Support Organization (conference fees and accommodation costs for invited speaker). The remaining authors have disclosed that they do not have any potential conflicts of interest.