Journal article
Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures
AJ Guy, V Irani, JG Beeson, B Webb, A Sali, JS Richards, PA Ramsland
Scientific Reports | NATURE PORTFOLIO | Published : 2018
Open access
Abstract
Humoral immune responses against the malaria parasite are an important component of a protective immune response. Antibodies are often directed towards conformational epitopes, and the native structure of the antigenic region is usually critical for antibody recognition. We examined the structural features of various Plasmodium antigens that may impact on epitope location, by performing a comprehensive analysis of known and modelled structures from P. falciparum. Examining the location of known polymorphisms over all available structures, we observed a strong propensity for polymorphic residues to be exposed on the surface and to occur in particular secondary structure segments such as hydro..
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Awarded by University of Melbourne
Funding Acknowledgements
Funding was provided by the National Health and Medical Research Council (NHMRC) of Australia including Fellowships to JSR (APP1037722) and JGB (APP1077636), Project (APP1125788) and Program (APP1092789) grants. Support was provided through Monash University (Australian Postgraduate Award to AJG) and the University of Melbourne (Melbourne International Fee Remission Scholarship and Melbourne International Research Scholarship to VI). The Burnet Institute is supported by the NHMRC Independent Research Institutes Infrastructure Support Scheme, and a Victoria State Government Operational Infrastructure Support grant. Funding was also provided by National Institutes of Health grants P41 GM109824 and R01 GM083960.