Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Virginie Deswaerte; Paul Nguyen; Alison West; Alison F Browning; Liang Yu; Saleela M Ruwanpura; Jesse Balic; Thaleia Livis; Charlotte Girard; Adele Preaudet; Hiroko Oshima; Ka Yee Fung; Hazel Tye; Meri Najdovska; Matthias Ernst; Masanobu Oshima; Cem Gabay; Tracy Putoczki; Brendan J Jenkins

Journal article

Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Virginie Deswaerte, Paul Nguyen, Alison West, Alison F Browning, Liang Yu, Saleela M Ruwanpura, Jesse Balic, Thaleia Livis, Charlotte Girard, Adele Preaudet, Hiroko Oshima, Ka Yee Fung, Hazel Tye, Meri Najdovska, Matthias Ernst, Masanobu Oshima, Cem Gabay, Tracy Putoczki, Brendan J Jenkins

Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2018

DOI: 10.1158/0008-5472.CAN-17-1887

University of Melbourne Researchers

Tracy Putoczki Author Surgery - Royal Melbourne Hospital

Ka Yee Fung Author Microbiology and Immunology

Matthias Ernst Author Surgery - Royal Melbourne Hospital

Grants

Funding Acknowledgements

We thank R. Smith and P. Bouillet for comments, K. Fitzgerald (University of Massachusetts Medical School, Worcester, MA) for providing Asc<SUP>-/-</SUP> mice, and C. Nold (Hudson Institute of Medical Research, Melbourne, Australia) for providing anakinra. This work was funded by the National Health and Medical Research Council (NHMRC) of Australia (to B. Jenkins), and the Operational Infrastructure Support Program by the Victorian Government of Australia. P. Nguyen, A. Browning, and J. Balic were supported by Australian Postgraduate Awards from the Australian Government, and A. West was supported by an NHMRC Early Career Fellowship. T. Putoczki was supported by a Victorian Cancer Agency Mid-Career Fellowship. B. Jenkins was supported by an NHMRC Senior Medical Research Fellowship.