Journal article

The risk of developing major depression among individuals with subthreshold depression: a systematic review and meta-analysis of longitudinal cohort studies

YY Lee, EA Stockings, MG Harris, SAR Doi, IS Page, SK Davidson, JJ Barendregt

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2019

Abstract

BACKGROUND: Studies have consistently shown that subthreshold depression is associated with an increased risk of developing major depression. However, no study has yet calculated a pooled estimate that quantifies the magnitude of this risk across multiple studies. METHODS: We conducted a systematic review to identify longitudinal cohort studies containing data on the association between subthreshold depression and future major depression. A baseline meta-analysis was conducted using the inverse variance heterogeneity method to calculate the incidence rate ratio (IRR) of major depression among people with subthreshold depression relative to non-depressed controls. Subgroup analyses were condu..

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University of Melbourne Researchers

Grants

Awarded by Australian Government National Health and Medical Research Council (NHMRC) Centre of Research Excellence in Mental Health Systems Improvement (CREMSI)


Awarded by NHMRC Early Career Fellowships


Funding Acknowledgements

This project was funded through the Australian Government National Health and Medical Research Council (NHMRC) Centre of Research Excellence in Mental Health Systems Improvement (CREMSI) (grant no. APP1041131). Authors ES (grant no. APP1104600) and SD (grant no. APP1071629) are both supported by NHMRC Early Career Fellowships. The views expressed in this manuscript are solely those of the authors and do not reflect the views of the NHMRC. The funding source had no involvement in the study design; the collection, analysis or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.