Journal article

Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants

Miquel A Fullana, Anton Albajes-Eizagirre, Caries Soriano-Mas, Bram Vervliet, Narcis Cardoner, Olivia Benet, Joaquim Radua, Ben J Harrison

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018

Abstract

The study of fear extinction represents an important example of translational neuroscience in psychiatry and promises to improve the understanding and treatment of anxiety and fear-related disorders. We present the results of a set of meta-analyses of human fear extinction studies in healthy participants, conducted with functional magnetic resonance imaging (fMRI) and reporting whole-brain results. Meta-analyses of fear extinction learning primarily implicate consistent activation of brain regions linked to threat appraisal and experience, including the dorsal anterior cingulate and anterior insular cortices. An overlapping anatomical result was obtained from the meta-analysis of extinction ..

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University of Melbourne Researchers

Grants

Awarded by Carlos III Health Institute (Spain)


Awarded by Fondo Europeo de Desarrollo Regional


Awarded by KU Leuven program


Awarded by Marie Curie International Outgoing Fellowship


Awarded by National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award


Funding Acknowledgements

This work was supported by "Miguel Servet" contracts from the Carlos III Health Institute (Spain) to Dr. Soriano-Mas (CP10/00604) and Dr. Radua (CP14/00041); from grants by the same institution and Fondo Europeo de Desarrollo Regional to Dr. Cardoner (PI12/01306; PI12/00273) and to Dr. Fullana (PI12/00273; PI16/00144); from a KU Leuven program funding grant (PF/10/005) and FP7 Marie Curie International Outgoing Fellowship (627743) to Dr. Vervliet. A/Prof. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (1124472).