Journal article

Frazzled can act through distinct molecular pathways in epithelial cells to regulate motility, apical constriction, and localisation of E-Cadherin

Sofia Golenkina, Vishal Chaturvedi, Robert Saint, Michael J Murray

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018

Abstract

Netrin receptors of the DCC/NEO/UNC-40/Frazzled family have well established roles in cell migration and axon guidance but can also regulate epithelial features such as adhesion, polarity and adherens junction (AJ) stability. Previously, we have shown that overexpression of Drosophila Frazzled (Fra) in the peripodial epithelium (PE) inhibits wing disc eversion and also generates cellular protrusions typical of motile cells. Here, we tested whether the molecular pathways by which Fra inhibits eversion are distinct from those driving motility. We show that in disc proper (DP) epithelial cells Fra, in addition to inducing F-Actin rich protrusions, can affect localization of AJ components and co..

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Grants

Awarded by Australian Research Council Discovery Project


Awarded by National Health and Medical Research Council Australia Project


Funding Acknowledgements

This work was supported by Australian Research Council Discovery Project DP120104443 to RS and National Health and Medical Research Council Australia Project Grant APP1107123 to MJM. SG was supported by a International Postgraduate Research Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.