Journal article

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

Ashfaqul Hogue, Priyadharshini Sivakumaran, Simon T Bond, Naomi XY Ling, Anne M Kong, John W Scott, Nadeeka Bandara, Damian Hernandez, Guei-Sheung Liu, Raymond CB Wong, Michael T Ryan, Derek J Hausenloy, Bruce E Kemp, Jonathan S Oakhill, Brian G Drew, Alice Pebay, Shiang Y Lim

Cell Death Discovery | NATURE PUBLISHING GROUP | Published : 2018

Grants

Awarded by Australian Research Council Future Fellowship


Awarded by Singapore Ministry of Health's National Medical Research Council


Awarded by Singapore Ministry of Education Academic Research Fund Tier 2


Awarded by European Cooperation in Science and Technology (COST Action)


Funding Acknowledgements

This work was carried out with support from the National Health and Medical Research Council of Australia (NHMRC) and St Vincent's Hospital (Melbourne) Research Endowment Fund. A.P. is supported by an Australian Research Council Future Fellowship (FT140100047). B.E.K. is an NHMRC fellow. R.C.B.W. is supported by Kel and Rosie Day Foundation and the University of Melbourne (Louisa Jean de Bretteville Bequest). Support was also provided by the Friedreich's Ataxia Research Alliance (research grant and 2012 Keith Michael Andrus Cardiac Research Award). D.J.H. is supported by the Duke-National University Singapore Medical School, and the National Institute for Health Research University College London Hospitals Biomedical Research Centre; the Singapore Ministry of Health's National Medical Research Council under its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/CGAug16C006); the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016-T2-2-021); and the European Cooperation in Science and Technology (COST Action CA16225/EU-CARDIOPROTECTION). The O'Brien Institute Department of St Vincent's Institute of Medical Research and the Centre for Eye Research Australia receive Operational Infrastructure Support from the Victorian State Government's Department of Innovation, Industry and Regional Development. We thank James A. Thomson (University of Wisconsin) for providing the iPS-Foreskin-2 cell line.