Porphyromonas Gingivalis Polypeptides Useful in the Prevention of Periodontal Disease
undefined DASHPER STUART GEOFFREY, undefined ANG CHING SENG, undefined VEITH PAUL DAVID, undefined REYNOLDS ERIC CHARLES
Published : 2007
The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.