PORPHYROMONAS GINGIVALIS POLYPEPTIDES USEFUL IN THE PREVENTION OF PERIODONTAL DISEASE
undefined REYNOLDS ERIC CHARLES, undefined ANG CHING SENG, undefined VEITH PAUL DAVID, undefined DASHPER STUART GEOFFREY
Published : 2007
The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that ca n be used in the prevention and treatment of periodontal disease. In particu lar, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the h ypothetical protein, PG1019 purported to be a cell surface lipoprotein and t he alkyl hydroperoxide reductase protein, PG0618 have been identified as use ful targets for the prevention and treatment of periodontal disease.