Monoclonal antibodies against Neisseria Gonorrhoeae : serotyping and diagnostic applications

Abstract

The aims of this study were (i) to investigate the value of newly developed monoclonal antibody coagglutination reagents for serotyping gonococci according to Protein I variation between strains; (ii) to determine if these or similar monoclonal antibodies could be used in an immunological method for the non -cultural detection of N. gonorrhoeae; and (iii) to produce monoclonal antibodies directed against gonococcal beta- lactamase and to examine their value in a non - cultural diagnostic test for penicillinase- producing gonococci. A total of 1201 gonococcal isolates, obtained from 967 patients attending a sexually transmitted diseases clinic in Edinburgh, were classified serologically using..