Journal article
Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial
SV Porceddu, M Bressel, MG Poulsen, A Stoneley, MJ Veness, LM Kenny, C Wratten, J Corry, S Cooper, GB Fogarty, M Collins, MK Collins, AMJ Macann, CG Milross, MG Penniment, HYH Liu, MT King, BJ Panizza, D Rischin
Journal of Clinical Oncology | AMER SOC CLINICAL ONCOLOGY | Published : 2018
Abstract
Purpose To report the results of the Trans Tasman Radiation Oncology Group randomized phase III trial designed to determine whether the addition of concurrent chemotherapy to postoperative radiotherapy (CRT) improved locoregional control in patients with high-risk cutaneous squamous cell carcinoma of the head and neck. Patients and Methods The primary objective was to determine whether there was a difference in freedom from locoregional relapse (FFLRR) between 60 or 66 Gy (6 to 6.5 weeks) with or without weekly carboplatin (area under the curve 2) after resection of gross disease. Secondary efficacy objectives were to compare disease-free survival and overall survival. Results Three hundred ..
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Funding Acknowledgements
Supported by the National Health and Medical Research Council-Australian Government, Cancer Council Queensland, and Queensland Government. M.T.K. was supported by the Australian government through Cancer Australia.