A three-generation study on the association of tobacco smoking with asthma
Simone Accordini, Lucia Calciano, Ane Johannessen, Laura Portas, Bryndis Benediktsdottir, Randi Jacobsen Bertelsen, Lennart Braback, Anne-Elie Carsin, Shyamali C Dharmage, Julia Dratva, Bertil Forsberg, Francisco Gomez Real, Joachim Heinrich, John W Holloway, Mathias Holm, Christer Janson, Rain Jogi, Benedicte Leynaert, Andrei Malinovschi, Alessandro Marcon Show all
International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2018
Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothe..View full abstract
Awarded by European Union's Horizon 2020 research and innovation programme
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study [www.alecstudy.org], which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212. The coordination of the European Community Respiratory Health Survey (ECRHS) was supported by the European Commission (phases 1 and 2) and the Medical Research Council (phase 3). Local funding agencies for the ECRHS are reported in the Supplementary Appendix, available as Supplementary data at IJE online.