Journal article

A comparison of nephron number, glomerular volume and kidney weight in Senegalese Africans and African Americans

Bridgette J McNamara, Boucar Diouf, Rebecca N Douglas-Denton, Michael D Hughson, Wendy E Hoy, John F Bertram

Nephrology Dialysis Transplantation | OXFORD UNIV PRESS | Published : 2010

Abstract

BACKGROUND: Low nephron number is determined in utero and is a proposed risk for essential hypertension. Glomerular volume is inversely correlated with nephron number, and genetic and environmental factors that determine nephron number are thought to determine glomerular volume. This study compared total glomerular (nephron) number (N(glom)), mean glomerular volume (V(glom)) and kidney weight in two geographically separated black populations with significant common genetic ancestry. METHODS: Unbiased stereology was used to determine N(glom) and V(glom) in kidneys collected at coronial autopsy in an age- and sex-matched sample of 39 adult Africans from Dakar in Senegal, West Africa and 39 Afr..

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Grants

Awarded by National Institutes of Health NIH


Awarded by NIH Center of Excellence in Minority Health


Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

The authors would like to acknowledge Sue Connell and Julie Hickey for their assistance in sectioning the tissue samples. PhD scholarship funding for B.J.M. was provided by an Australian Postgraduate Award and a Faculty of Medicine Dean's Excellence Award. Partial support for this work was provided by grants from the National Institutes of Health NIH 1 RO1 DK065970-01, NIH Center of Excellence in Minority Health 5P20M00534-02 and National Health and Medical Research Council (NHMRC) Program grant 502009. Glomerular counts for African American kidneys were performed by R.N.D.-D. for previous publications [ 1,15,19].