Journal article

Renal pathology, glomerular number and volume in a West African urban community

Bridgette J McNamara, Boucar Diouf, Michael D Hughson, Rebecca N Douglas-Denton, Wendy E Hoy, John F Bertram

Nephrology Dialysis Transplantation | OXFORD UNIV PRESS | Published : 2008


BACKGROUND: Low glomerular number and large glomerular volume are hypothesized to be risk factors for hypertensive renal disease in adult life. Reports of human glomerular number are based on studies from developed nations and have found single kidney mean values of approximately 900 000 per kidney with a roughly 8-fold range matched by a similar range in glomerular volume. Glomerular number and volume have never been investigated in people from a developing country. METHODS: This study analysed the pathology of 81 autopsy kidneys from Dakar, Senegal, and determined total glomerular number and mean glomerular volume in 28 of these kidneys using the physical disector/fractionator method. RESU..

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