Journal article

An Acute, Double-Blind, Placebo-Controlled Crossover Study of 320mg and 640mg Doses of a Special Extract of Bacopa monnieri (CDRI 08) on Sustained Cognitive Performance

Luke A Downey, James Kean, Fiona Nemeh, Angela Lau, Alex Poll, Rebecca Gregory, Margaret Murray, Johanna Rourke, Brigit Patak, Matthew P Pase, Andrea Zangara, Justine Lomas, Andrew Scholey, Con Stough



Standardized extracts of the traditional Ayurvedic medicine Bacopa monnieri (BM) (Brahmi) have been recently shown to have cognitive enhancing effects in chronic administration studies. Pre-clinical work has also identified a number of acute anxiolytic, nootropic, and cardiovascular effects of BM. There has, however, been little research on the acute effects of BM on cognitive function. The current study aimed to assess the acute effects of a specific extract of BM (KeenMind®-CDRI 08) in a double-blind, placebo-controlled study in normal healthy participants who completed a cognitively demanding series of tests. Twenty-four healthy volunteers completed six repetitions of the Cognitive Demand..

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University of Melbourne Researchers


Awarded by Australian Research Council

Funding Acknowledgements

The study was funded by an Australian Research Council Discovery grant (DP1093825) to Prof Con Stough, Andrew Scholey, and Kevin Croft and funding from Soho Flordis International (SFI) who also provided the special extract of BM (CDRI 08) and placebo used in this study. Andrea Zangara is employed by SFI as Research and Development Director.