Journal article

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation

Ales Hnizda, Milan Fabry, Takaya Moriyama, Petr Pachl, Michael Kugler, Vitezslav Brinsa, David B Ascher, William L Carroll, Petr Novak, Marketa Zaliova, Jan Trka, Pavlina Rezacova, Jun J Yang, Vaclav Veverka

Leukemia | NATURE PUBLISHING GROUP | Published : 2018

Grants

Awarded by Czech Science Foundation


Awarded by Ministry of Education of the Czech Republic


Awarded by European Regional Development Fund Project


Awarded by Academy of Sciences of the Czech Republic


Awarded by Czech Health Research Council


Awarded by Charles University


Awarded by National Health and Medical Research Council of Australia


Awarded by Jack Brockhoff Foundation


Funding Acknowledgements

This work was supported by grant 15-06582S from the Czech Science Foundation and in part by the Ministry of Education of the Czech Republic (program "NPU I" LO1304 and program "InterBioMed" LO1302) and by European Regional Development Fund Project No. CZ.02.1.01/0.0/0.0/16_019/0000729. Institutional support was provided by projects RVO 61388963 and 68378050 of the Academy of Sciences of the Czech Republic. MZ and JT were funded by grant 15-30626A from Czech Health Research Council and grant Primus/MED/28 from Charles University. DBA was supported by a C. J. Martin Research Fellowship from the National Health and Medical Research Council of Australia (APP1072476) and the Jack Brockhoff Foundation (JBF 4186, 2016). We acknowledge beamline access at MX14.1 and MX14.3 of the BESSY (HZB Berlin, Germany) to collect crystal diffraction data. The authors would like to thank Irena Sieglova, MSc and Anna Soldanova, BSc for technical help during protein preparations and Katsiaryna Tratsiak, MSc for crystallization trials.