Complexity and Distribution of Drivers in Relation to Duration of Persistent Atrial Fibrillation.
Han S Lim, Mélèze Hocini, Remi Dubois, Arnaud Denis, Nicolas Derval, Stephan Zellerhoff, Seigo Yamashita, Benjamin Berte, Saagar Mahida, Yuki Komatsu, Matthew Daly, Laurence Jesel, Carole Pomier, Valentin Meillet, Sana Amraoui, Ashok J Shah, Hubert Cochet, Frédéric Sacher, Pierre Jaïs, Michel Haïssaguerre
J Am Coll Cardiol | Published : 2017
BACKGROUND: The underlying mechanisms sustaining human persistent atrial fibrillation (PsAF) is poorly understood. OBJECTIVES: This study sought to investigate the complexity and distribution of AF drivers in PsAF of varying durations. METHODS: Of 135 consecutive patients with PsAF, 105 patients referred for de novo ablation of PsAF were prospectively recruited. Patients were divided into 3 groups according to AF duration: PsAF presenting in sinus rhythm (AF induced), PsAF 12 months. Patients wore a 252-electrode vest for body surface mapping. Localized drivers (re-entrant or focal) were identified using phase-mapping algorithms. RESULTS: In this patient cohort, the most prominent re-entrant..View full abstract