Journal article

The Effect of Mammary Extracellular Matrix in Controlling Oral and Mammary Cancer Cells

Sivapriya Pavuluri, Julie A Sharp, Christophe Lefevre, Kevin R Nicholas

Asian Pac J Cancer Prev | Published : 2018


Extracellular matrix (ECM) plays an important role in the normal physiology of tissues and progression to disease. Earlier studies and our external microarray data analysis indicated that mammary matrix from involuting tissue showed upregulation of genes involved in ECM remodeling. The present study examines the fate of mammary and oral cancer cells grown in the ECM from lactating mammary gland. Our findings show that non-tumorigenic cells, MCF10A and DOK cells did not proliferate but the tumorigenic and metastatic cells, SCC25 and MDA-MB-231, underwent apoptosis when grown on mammary ECM isolated from lactating mice. In addition, the cytokinesis marker, CEP55, was repressed in the oral and ..

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