Journal article

Adult height is associated with increased risk of ovarian cancer: A Mendelian randomisation study

SC Dixon-Suen, CM Nagle, AP Thrift, PDP Pharoah, A Ewing, CL Pearce, W Zheng, G Chenevix-Trench, PA Fasching, MW Beckmann, D Lambrechts, I Vergote, S Lambrechts, E Van Nieuwenhuysen, MA Rossing, JA Doherty, KG Wicklund, J Chang-Claude, AY Jung, KB Moysich Show all

British Journal of Cancer | NATURE PUBLISHING GROUP | Published : 2018

Abstract

Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Results: Greater ge..

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Grants

Awarded by Mayo Foundation for Medical Education and Research


Funding Acknowledgements

This work was supported by: the National Cancer Institute at the U.S. National Institutes of Health [K07-CA095666, K07-CA80668, K07-CA143047, K22-CA138563, N01-CN025403, N01-CN55424, N01-PC67001, N01-PC67010, P01-CA17054, P30-CA072720, P30-CA008748, P30-CA14089, P30-CA15083, P50-CA105009, P50-CA136393, P50-CA159981, R01-CA058860, R01 CA063678, R01 CA063682, R01-CA092044, R01-CA095023, R01-CA16056, R01-CA54419, R01-CA58598, R01-CA61107, R01-CA61132, R01-CA76016, R01-CA83918, R01-CA87538, R01-CA112523, R01-CA122443, R03-CA113148, R03-CA115195, U01-CA69417, U01-CA71966 and Intramural Research funds]; the European Commission's Seventh Framework Programme [agreement number 223175 HEALTH F2 2009-223175]; Cancer Research UK [C490/A16561, C536/A13086, C536/A6689, C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692 and C8197/A16565]; a National Institutes of Health (CA128978), Cancer Post-GWAS Initiative [1U19 CA148537, 1U19 CA148065 and 1U19 CA148112-the Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative]; the U.S. Department of Defense [DAMD17-02-1-0669, W81XWH-07-0449, DAMD17-02-1-0666, W81XWH-10-1-0280 and W81XWH-10-1-0341]; the Canadian Institutes of Health Research (CIHR) [MOP-86727 and MSH-87734 to L.E.K.] and the CIHR Team in Familial Risks of Breast Cancer; the Komen Foundation for the Cure; the Breast Cancer Research Foundation; the Ovarian Cancer Research Fund (thanks to donations by the family and friends of Kathryn Sladek Smith); the U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729 and DAMD17-02-1-0669]; the National Health and Medical Research Council of Australia [199600, 209057, 251553, 400281, 504711, 1073898 and fellowships to G.C.-T. and P.M.W.]; Cancer Councils of Queensland, Victoria, New South Wales, South Australia and Tasmania and the Cancer Foundation of Western Australia [Multi-State Grant Applications 191, 211 and 182]; VicHealth; the ELAN Program of the University of Erlangen-Nuremberg; the Nationaal Kankerplan of Belgium; the German Federal Ministry of Education and Research of Germany Programme of Clinical Biomedical Research [01 GB 9401]; the German Cancer Research Center; the Roswell Park Cancer Institute Alliance Foundation [P30 CA016056]; the Rudolf-Bartling Foundation; the Helsinki University Central Hospital Research Fund; the National Institutes of Health/National Center for Research Resources/General Clinical Research Center [M01-RR000056]; an American Cancer Society Early Detection Professorship [SIOP-06-258-01-COUN to B.Y.K.]; the National Center for Advancing Translational Sciences (NCATS) [UL1TR000124 to B.Y.K.]; the Danish Cancer Society [94-222-52]; the Mermaid I project; the Mayo Foundation; the Minnesota Ovarian Cancer Alliance; the Fred C. and Katherine B. Andersen Foundation; the Cancer Institute of New Jersey; Helse Vest; the Norwegian Cancer Society; the Research Council of Norway; Radboud University Medical Centre; the Oregon Health and Science University (OHSU) Foundation; Pomeranian Medical University; the UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge, University College London Hospital, and the Royal Marsden Hospital; the Imperial Experimental Cancer Research Centre [C1312/A15589]; the U.S. Public Health Service [PSA-042205]; the Lon V. Smith Foundation [LVS-39420]; The Eve Appeal; The Oak Foundation; the California Cancer Research Program [00-01389V-20170 and 2II0200]; the Polish Ministry of Science and Higher Education [4 PO5C 028 14 and 2 PO5A 068 27]; and the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw.