Journal article
Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review
X Dai, G Bowatte, AJ Lowe, MC Matheson, LC Gurrin, JA Burgess, SC Dharmage, CJ Lodge
Current Allergy and Asthma Reports | CURRENT MEDICINE GROUP | Published : 2018
Abstract
Purpose of Review: Glutathione S-transferase (GST) genes are involved in oxidative stress management and may modify the impact of indoor air pollution. We aimed to assess the influence of GST genes on the relationship between indoor air pollution and allergy/lung function. Recent Findings: Our systematic review identified 22 eligible studies, with 15 supporting a gene-environment interaction. Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits. However, findings differed in terms of risk alleles and specific exposures. High-exposure heterogeneity precluded meta-analysis. Summary: ..
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Funding Acknowledgements
Xin Dai, Prof. Shyamali Dharmage, Dr. Caroline Lodge, Dr. Melanie Matheson, and Dr. Adrian Lowe are funded by the National Health and Medical Research Council of Australia (NHMRC); Dr. John Burgess and Gayan Bowatte have no personal funding relationships to declare.