Journal article
The stability of neuropsychiatric subsyndromes in Alzheimer's disease
MH Connors, KM Seeher, J Crawford, D Ames, M Woodward, H Brodaty
Alzheimer S and Dementia | ELSEVIER SCIENCE INC | Published : 2018
Abstract
Introduction: Neuropsychiatric symptoms are common in Alzheimer's disease. Previous research has attempted to identify subsyndromes—sets of symptoms related to one another—to clarify underlying mechanisms and treatment targets. We examined the stability of these subsyndromes over time. Methods: We administered the Neuropsychiatric Inventory annually for 3 years to 447 patients with Alzheimer's disease recruited from memory clinics. We conducted principal component analyses at each time point and multiple-group confirmatory factor analyses across time. Results: Principal component analyses showed that no two time points shared the same factor structure. Factor solutions did not exhibit strong..
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Funding Acknowledgements
The Dementia Centre for Research Collaboration is funded by the National Health and Medical Research Council. The study was funded in part by Janssen-Cilag Pty Limited. Janssen Cilag had no input into the design, execution, analysis, interpretation, or writing of this study. The authors thank all the investigators, study nurses, staff, and hospitals who were involved in PRIME study: Prince of Wales Hospital (Marika Donkin, Louisa Gibson, Kim Burns, and Claire Thompson); The Queen Elizabeth Hospital (Shelley Casey and Trish Steventon); St George's Hospital (Maree Mastwyk, Alissa Westphal, Nicola Lautenschlager, Olga Yastrubetskaya, Marilyn Kemp, Edmond Chiu, and Jennifer Ames); Austin Health Repatriation Hospital (Irene Tan, Henry Zeimer, and Leonie Johnston); Hornsby Ku-Ring-Gai Hospital (Sue Kurile, Roseanne Hogarth, and Judith Allan); Fremantle Hospital (Roger Clarnette, Janice Guy, and Denae Clark); The Prince Charles Hospital (Chris Davis, Mary Wyatt, Katrina Brosnan, and Margaret Morton); Rankin Park Hospital (John Ward and Jeanette Gatgens); and Geelong Private Hospital (Alastair Mander and Bernadine Charles). We also thank the patients and caregivers who supported the study.