Journal article

PROVIRAL INTEGRATION SITE MIS-1 IN RAT THYMOMAS CORRESPONDS TO THE PVT-1 TRANSLOCATION BREAKPOINT IN MURINE PLASMACYTOMAS

L VILLENEUVE, E RASSART, P JOLICOEUR, M GRAHAM, JM ADAMS

Molecular and Cellular Biology | AMER SOC MICROBIOLOGY | Published : 1986

Abstract

Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral integration site in retrovirally induced rat T lymphomas, while the pvt-1 locus on murine chromosome 15 frequently translocates to the kappa locus in plasmacytomas bearing 6;15 translocations. By comparing cloned sequences, we show that pvt-1 is the murine homolog of Mis-1.

University of Melbourne Researchers