Butyrate increases apoptosis induced by different antineoplastic drugs in monocytic leukemia cells.
MG Ramos, FLA Rabelo, G Brumatti, AE Bueno-da-Silva, GP Amarante-Mendes, JI Alvarez-Leite
Chemotherapy | Published : 2004
BACKGROUND: Apoptosis is an essential form of cell death, the failure of which can lead to cancer development. Cancer including leukemia is usually treated with chemotherapeutic drugs that can be effective, but frequently problems are encountered that impair the success of the treatment. Butyrate is a short-chain fatty acid that can have many effects on different cells, including apoptosis. METHODS: The effect of a combination treatment with butyrate and antineoplastic agents Ara-C, etoposide and vincristine is evaluate on the leukemic cell line THP-1. RESULTS: We show that butyrate increased apoptosis induced by the three agents as seen by measurement of DNA content, annexin exposure and mo..View full abstract