Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis
Zoe K McQuilten, Craig J French, Alistair Nichol, Alisa Higgins, David J Cooper
Transfusion Medicine Reviews | W B SAUNDERS CO-ELSEVIER INC | Published : 2018
Longer storage duration of red blood cell (RBC) units prior to transfusion has been associated with worse outcomes in observational studies. We performed a systematic review, including recently published randomized trials, to determine if storage age of RBCs is associated with mortality, morbidity or adverse events in patients. Searches were performed up to 21st July 2017 in Medline (OvidSP), 20 July in EMBASE (OvidSP) and June 2017 in Cochrane Library. Eligible studies were randomized controlled trials comparing transfusion of fresher or freshest available with older or standard issue RBCs. Human volunteer and autologous RBC transfusion studies were excluded. Data were extracted from publis..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship
Awarded by NHMRC Practitioner Fellowship
Awarded by NHMRC Centre for Research Excellence in Patient Blood Management in Critical Care and Trauma
We thank Georgina Imberger for advice on the statistical analysis. ZM is supported by an Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1111485), AN by an Irish Health Research Board-Clinical Trial Network award and DJC is supported by a NHMRC Practitioner Fellowship (APP436629). This study was supported by the NHMRC Centre for Research Excellence in Patient Blood Management in Critical Care and Trauma (APP1049071).