Journal article

Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis

Zoe K McQuilten, Craig J French, Alistair Nichol, Alisa Higgins, David J Cooper

Transfusion Medicine Reviews | W B SAUNDERS CO-ELSEVIER INC | Published : 2018

Abstract

Longer storage duration of red blood cell (RBC) units prior to transfusion has been associated with worse outcomes in observational studies. We performed a systematic review, including recently published randomized trials, to determine if storage age of RBCs is associated with mortality, morbidity or adverse events in patients. Searches were performed up to 21st July 2017 in Medline (OvidSP), 20 July in EMBASE (OvidSP) and June 2017 in Cochrane Library. Eligible studies were randomized controlled trials comparing transfusion of fresher or freshest available with older or standard issue RBCs. Human volunteer and autologous RBC transfusion studies were excluded. Data were extracted from publis..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship


Awarded by NHMRC Practitioner Fellowship


Awarded by NHMRC Centre for Research Excellence in Patient Blood Management in Critical Care and Trauma


Funding Acknowledgements

We thank Georgina Imberger for advice on the statistical analysis. ZM is supported by an Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1111485), AN by an Irish Health Research Board-Clinical Trial Network award and DJC is supported by a NHMRC Practitioner Fellowship (APP436629). This study was supported by the NHMRC Centre for Research Excellence in Patient Blood Management in Critical Care and Trauma (APP1049071).