Journal article

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease

Ci Song, Stephen Burgess, John D Eicher, Christopher J O'Donnell, Andrew D Johnson

JOURNAL OF THE AMERICAN HEART ASSOCIATION | WILEY | Published : 2017

Abstract

BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. METHODS AND RESULTS: To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD using a Mendelian ..

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