Journal article
Baseline Amnestic Severity Predicts Progression from Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years
NI Bradfield, KA Ellis, G Savage, P Maruff, S Burnham, D Darby, NT Lautenschlager, RN Martins, CL Masters, SR Rainey-Smith, J Robertson, C Rowe, M Woodward, D Ames
Alzheimer Disease and Associated Disorders | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Abstract
Background: Given the long preclinical disease course of Alzheimer disease (AD) pathology, novel treatments may be more efficacious if administered before the emergence of dementia. Thus, accurate prediction of who will develop AD dementia is of key importance in selecting individuals for trials of treatment and may become crucial for future selection of patients for therapy. Methods: As part of the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing, 901 individuals who did not have dementia were recruited. We assigned individuals according to Petersen criteria and Winblad criteria for Mild Cognitive Impairment (MCI) at baseline. We then stratified individuals with amnesti..
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Funding Acknowledgements
For the first 3 years of operation the AIBL study was funded by CSIRO and in-kind contributions from the University of Melbourne Department of Psychiatry, Mental Health Research Institute of Victoria, Austin PET Centre and Edith Cowan University.