Journal article

Impaired fornix-hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis

PS Baumann, A Griffa, M Fournier, P Golay, C Ferrari, L Alameda, M Cuenod, J-P Thiran, P Hagmann, KQ Do, P Conus

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2016

Abstract

Several lines of evidence implicate the fornix-hippocampus circuit in schizophrenia. In early-phase psychosis, this circuit has not been extensively investigated and the underlying mechanisms affecting the circuit are unknown. The hippocampus and fornix are vulnerable to oxidative stress at peripuberty in a glutathione (GSH)-deficient animal model. The purposes of the current study were to assess the integrity of the fornix-hippocampus circuit in early-psychosis patients (EP), and to study its relationship with peripheral redox markers. Diffusion spectrum imaging and T1-weighted magnetic resonance imaging (MRI) were used to assess the fornix and hippocampus in 42 EP patients compared with 42..

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Grants

Awarded by Swiss National Science Foundation


Awarded by National Center of Competence in Research (NCCR) 'SYNAPSY - The Synaptic Bases of Mental Diseases' - Swiss National Science Foundation


Funding Acknowledgements

We are grateful for technical assistance to Helene Moser and Adeline Cottier. We thank all patients and volunteers for their enduring participation. This work was supported by the Swiss National Science Foundation (320030-130090 to PH, 320030_122419 to PC and KQD), National Center of Competence in Research (NCCR) 'SYNAPSY - The Synaptic Bases of Mental Diseases' financed by the Swiss National Science Foundation (no. 51AU40_125759) and the foundations Avina, Damm-Etienne and Alamaya. PH was financially supported by Leenaards Foundation.