Influence of polygenic risk scores on lipid levels and dyslipidemia in a psychiatric population receiving weight gain-inducing psychotropic drugs
Aurelie Delacretaza, Patricia Lagares Santos, Nuria Saigi Morgui, Frederik Vandenberghe, Anais Glatard, Mehdi Gholam-Rezaee, Armin von Gunten, Philippe Conus, Chin B Eap
PHARMACOGENETICS AND GENOMICS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
OBJECTIVES: Dyslipidemia represents a major health issue in psychiatry. We determined whether weighted polygenic risk scores (wPRSs) combining multiple single-nucleotide polymorphisms (SNPs) associated with lipid levels in the general population are associated with lipid levels [high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides] and/or dyslipidemia in patients receiving weight gain-inducing psychotropic drugs. We also determined whether genetics improve the predictive power of dyslipidemia. PATIENTS AND METHODS: The influence of wPRS on lipid levels was firstly assessed in a discovery psychiatric sample (n=332) and was then tested for re..View full abstract
Awarded by Swiss National Research Foundation
This work has been funded in part by the Swiss National Research Foundation (C.B.E. and P.C.: 320030-120686, 324730-144064 and 320030-173211).