Journal article

Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs

Aurelie Delacretaz, Adna Zdralovic, Frederik Vandenberghe, Nuria Saigi-Morgui, Anais Glatard, Lina Quteineh, Mehdi Gholam-Rezaee, Wassim Raffoul, Lee Ann Applegate, Paris Jafari, Franziska Gamma, Armin von Gunten, Philippe Conus, Chin B Eap

GENE | ELSEVIER | Published : 2017

Abstract

Genetic factors associated with Body Mass Index (BMI) have been widely studied over the last decade. We examined whether genetic variants previously associated with BMI in the general population are associated with cardiometabolic parameter worsening in the psychiatric population receiving psychotropic drugs, a high-risk group for metabolic disturbances. Classification And Regression Trees (CARTs) were used as a tool capable of describing hierarchical associations, to pinpoint genetic variants best predicting worsening of cardiometabolic parameters (i.e total, HDL and LDL-cholesterol, triglycerides, body mass index, waist circumference, fasting glucose, and blood pressure) following prescrip..

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