Journal article

Treatment in early psychosis with N-acetyl-cysteine for 6 months improves low-level auditory processing: Pilot study

Chrysa Retsa, Jean-Francois Knebel, Eveline Geiser, Carina Ferrari, Raoul Jenni, Margot Fournier, Luis Alameda, Philipp S Baumann, Stephanie Clarke, Philippe Conus, Kim Q Do, Micah M Murray



Sensory impairments constitute core dysfunctions in schizophrenia. In the auditory modality, impaired mismatch negativity (MMN) has been observed in chronic schizophrenia and may reflect N-methyl-d-aspartate (NMDA) hypo-function, consistent with models of schizophrenia based on oxidative stress. Moreover, a recent study demonstrated deficits in the N100 component of the auditory evoked potential (AEP) in early psychosis patients. Previous work has shown that add-on administration of the glutathione precursor N-acetyl-cysteine (NAC) improves the MMN and clinical symptoms in chronic schizophrenia. To date, it remains unknown whether NAC also improves general low-level auditory processing and i..

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Awarded by Swiss National Science Foundation

Awarded by Swiss National Science Foundation (National Centre of Competence in Research project "SYNAPSY, The Synaptic Bases of Mental Disease")

Funding Acknowledgements

Financial support was provided by the Swiss National Science Foundation (grants: 320030_149982 and 320030_169206 to M.M.M.; 320030_122419 to P.C. and K.Q.D.; PZOOP1_148184 to E.G., and the National Centre of Competence in Research project "SYNAPSY, The Synaptic Bases of Mental Disease" [project 51NF40-158776]), the Damm-Etienne and Alamaya Foundations and the Swiss Brain League (2014 Research Prize to M.M.M.). P.S.B. is supported by the Leenaards foundation. These sources had no further role in this study design, in the data collection and analysis, in the writing of the report, and in the decision to submit the paper for publication.