Journal article

Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression

Aurelie Delacretaz, Martin Preisig, Frederik Vandenberghe, Nuria Saigi Morgui, Lina Quteineh, Eva Choong, Mehdi Gholam-Rezaee, Zoltan Kutalik, Pierre Magistretti, Jean-Michel Aubry, Armin von Gunten, Enrique Castelao, Peter Vollenweider, Gerard Waeber, Philippe Conus, Chin B Eap

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 ..

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Grants

Awarded by Swiss National Research Foundation


Awarded by National Center of Competence in Research "SYNAPSY-The Synaptic Bases of Mental Diseases" - Swiss National Science Foundation


Awarded by Swiss National Science Foundation


Funding Acknowledgements

This work has been funded in part by the Swiss National Research Foundation grants 320030120686 and 324730-144064 (CBE and PC) and by the National Center of Competence in Research "SYNAPSY-The Synaptic Bases of Mental Diseases" financed by the Swiss National Science Foundation grant 51AU40_125759. The CoLaus vertical bar PsyCoLaus study was and is supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and the Swiss National Science Foundation (grants 3200B0-105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468 and 33CS30-148401). ZK received support from the Leenaards Foundation and the Swiss National Science Foundation (31003A-143914). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.