Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments.
Núria Saigi-Morgui, Frederik Vandenberghe, Aurélie Delacrétaz, Lina Quteineh, Eva Choong, Mehdi Gholamrezaee, Pierre Magistretti, Jean-Michel Aubry, Armin von Gunten, Martin Preisig, Enrique Castelao, Peter Vollenweider, Gerard Waeber, Zoltán Kutalik, Philippe Conus, Chin B Eap
J Clin Psychopharmacol | Published : 2015
Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism. Phosphoenolpyruvate carboxykinase 1 is a rate-controlling enzyme involved in gluconeogenesis, glyceroneogenesis and cataplerosis and has been related to obesity and diabetes phenotypes in animals and humans. The aim of this study was to investigate the association of phosphoenolpyruvate carboxykinase 1 polymorphisms with metabolic traits in psychiatric patients treated with psychotropic drugs inducing weight gain and in general population samples. One polymorphism (rs11552145G > A) significantly associated with body mass index in the psy..View full abstract