Conference Proceedings

Developing Psychosis and Its Risk States Through the Lens of Schizotypy

Martin Debbane, Stephan Eliez, Deborah Badoud, Philippe Conus, Rahel Flueckiger, Frauke Schultze-Lutter



Starting from the early descriptions of Kraepelin and Bleuler, the construct of schizotypy was developed from observations of aberrations in nonpsychotic family members of schizophrenia patients. In contemporary diagnostic manuals, the positive symptoms of schizotypal personality disorder were included in the ultra high-risk (UHR) criteria 20 years ago, and nowadays are broadly employed in clinical early detection of psychosis. The schizotypy construct, now dissociated from strict familial risk, also informed research on the liability to develop any psychotic disorder, and in particular schizophrenia-spectrum disorders, even outside clinical settings. Against the historical background of sch..

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Awarded by Swiss National Science Foundation

Awarded by Gertrude Von Meissner Foundation

Awarded by Swiss National Research Fund

Funding Acknowledgements

Swiss National Science Foundation (100014-135311/1 to M.D.); Gertrude Von Meissner Foundation (ME 7871); National Center of Competence in Research (M.D., S.E., and P.C.); Swiss National Research Fund (51AU40-125759 to "SYNAPSY-The Synaptic Bases of Mental Diseases"); Swiss National Science Foundation (135381 and 144100 to F.S.L.).