White matter correlates of episodic memory encoding and retrieval in schizophrenia
Amity E Green, Rodney J Croft, Jerome J Maller, Paul B Fitzgerald
PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2016
Episodic memory (EM) impairments in schizophrenia (SZ) are predictive of functional outcome and are a potential endophenotype of the disorder. The current study investigated the neuroanatomical correlates of EM encoding and retrieval in SZ with structural magnetic resonance and diffusion tensor imaging (DTI) measures in 22 patients with SZ and 22 age- and gender-matched healthy controls. Tract-based Spatial Statistics (TBSS) was used to investigate microstructural alterations in white matter (WM), while FreeSurfer surface-based analysis was used to determine abnormalities in grey matter (GM) and WM volumetrics and cortical thickness. Compared to controls, patients demonstrated GM deficits in..View full abstract
Awarded by National Health and Medical Research Council, Australia
Awarded by NHMRC practitioner Fellowship
This study was funded by the National Health and Medical Research Council, Australia (Project Grant 502910). Paul B. Fitzgerald is supported by a NHMRC practitioner Fellowship (1078567).