Journal article

Ventricular Enlargement and its Clinical Correlates in the Imaging Cohort From the ADCS MCI Donepezil/Vitamin E Study

Liana G Apostolova, Sona Babakchanian, Kristy S Hwang, Amity E Green, Dimitar Zlatev, Yi-Yu Chou, Charlie DeCarli, Clifford R Jack, Ronald C Petersen, Paul S Aisen, Jeffrey L Cummings, Arthur W Toga, Paul M Thompson

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013

Abstract

We analyzed the baseline and 3-year T1-weighted magnetic resonance imaging data of 110 amnestic mild cognitive impairment (MCI) participants with minimal hippocampal atrophy at baseline from the Alzheimer's Disease Cooperative Study group MCI Donepezil/Vitamin E trial. Forty-six subjects converted to Alzheimer disease (AD) (MCIc), whereas 64 remained stable (MCInc). We used the radial distance technique to examine the differences in lateral ventricle shape and size between MCIc and MCInc and the associations between ventricular enlargement and cognitive decline. MCIc group had significantly larger frontal and right body/occipital horns relative to MCInc at baseline and significantly larger b..

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Awarded by NIA


Awarded by NIBIB


Awarded by NLM


Awarded by NCRR


Awarded by NIMH


Awarded by NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE ON AGING


Awarded by NATIONAL LIBRARY OF MEDICINE


Funding Acknowledgements

Supported by NIA U01 AG10483, NIA K23 AG026803 (jointly sponsored by NIA, AFAR, The John A. Hartford Foundation, The Atlantic Philanthropies, The Starr Foundation, and an anonymous donor; L. G. A.); the Turken Foundation (L. G. A.); NIA AG16570 (L. G. A., J.L.C., and P. M. T.); NIBIB EB01651, NLM LM05639, NCRR RR019771 (P. M. T.); and NIMH R01 MH071940, NCRR P41 RR013642 and NIH U54 RR021813 (A.W.T.).The authors thank all research subjects for participating in this trial, all evaluating clinicians and staff members for data collection, and the ADCS group for their support.