Journal article

Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer's Disease Neuroimaging Initiative

N Chow, KS Hwang, S Hurtz, AE Green, JH Somme, PM Thompson, DA Elashoff, CR Jack, M Weiner, LG Apostolova

AMERICAN JOURNAL OF NEURORADIOLOGY | AMER SOC NEURORADIOLOGY | Published : 2015

Abstract

BACKGROUND AND PURPOSE: Prior MR imaging studies, primarily at 1.5T, established hippocampal atrophy as a biomarker for Alzheimer disease. 3T MR imaging offers a higher contrast and signal-to-noise ratio, yet distortions and intensity uniformity are harder to control. We applied our automated hippocampal segmentation technique to 1.5T and 3T MR imaging data, to determine whether hippocampal atrophy detection was enhanced at 3T. MATERIALS AND METHODS: We analyzed baseline MR imaging data from 166 subjects from the Alzheimer's Disease Neuroimaging Initiative-1 (37 with Alzheimer disease, 76 with mild cognitive impairment, and 53 healthy controls) scanned at 1.5T and 3T. Using multiple linear r..

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Grants

Awarded by Easton Consortium for Alzheimer Drug Discovery and Biomarkers, National Institutes of Health


Awarded by National Imaging Associates


Awarded by National Institute of Biomedical Imaging and Bioengineering


Awarded by National Library of Medicine


Awarded by National Center for Research Resources


Awarded by National Institutes of Health


Awarded by ADNI National Imaging Associates


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE ON AGING


Awarded by NATIONAL LIBRARY OF MEDICINE


Funding Acknowledgements

This work was generously supported by the Easton Consortium for Alzheimer Drug Discovery and Biomarkers, National Institutes of Health R01 AG040770, National Imaging Associates K23 AG026803, National Imaging Associates P50 AG16570, National Institute of Biomedical Imaging and Bioengineering EB008561, National Institute of Biomedical Imaging and Bioengineering EB01651, National Library of Medicine LM05639, National Center for Research Resources RR019771 and National Institutes of Health RR021813, and the ADNI National Imaging Associates U01AG024904.