Journal article
Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke
MA Evans, R Lim, HA Kim, HX Chu, CV Gardiner-Mann, KWE Taylor, CT Chan, VH Brait, S Lee, QN Dinh, A Vinh, TG Phan, VK Srikanth, H Ma, TV Arumugam, DY Fann, L Poh, CPJ Hunt, CW Pouton, JM Haynes Show all
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Abstract
Background and Purpose - Human amnion epithelial cells (hAECs) are nonimmunogenic, nontumorigenic, antiinflammatory cells normally discarded with placental tissue. We reasoned that their profile of biological features, wide availability, and the lack of ethical barriers to their use could make these cells useful as a therapy in ischemic stroke. Methods - We tested the efficacy of acute (1.5 hours) or delayed (1-3 days) poststroke intravenous injection of hAECs in 4 established animal models of cerebral ischemia. Animals included young (7-14 weeks) and aged mice (20-22 months) of both sexes, as well as adult marmosets of either sex. Results - We found that hAECs administered 1.5 hours after s..
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Funding Acknowledgements
These studies were supported by a Grant-In-Aid (G11M5907) from the Heart Foundation of Australia. We acknowledge support from a Contributing to Australian Scholarship and Science Foundation grant (Dr Broughton), Monash Strategic Grant (Dr Broughton), Monash Faculty Postgraduate Scholarship (Dr Evans), Australian Postgraduate Awards (Drs Chu, Chan, and Dinh), National Stroke Foundation Honours Grant (C.V. Gardiner-Mann), Monash Postgraduate Research Scholarship (Dr Brait), New Zealand Lottery Health Postdoctoral Fellowship (Dr Neumann), Australian Research Council Future Fellowship (Dr Arumugam), National Health and Medical Research Council of Australia Senior Research Fellowships (Drs Drummond and Sobey), National Health and Medical Research Council of Australia Project Grant (Drs Wallace and Lim), New Zealand Neurological Foundation and Royal Society of New Zealand Project Grant (Dr Clarkson), Maurice and Phyllis Paykel Trust (Dr Clarkson), and Victorian Government's Operational Infrastructure Support Program (Drs Wallace and Lim).