Expression pattern of CYP24 in liver during ageing in long-term diabetes
Ana Vuica, Katarina Vukojevic, Lejla Ferhatovic Hamzic, Milka Jeric, Livia Puljak, Ivica Grkovic, Natalija Filipovic
ACTA HISTOCHEMICA | ELSEVIER GMBH, URBAN & FISCHER VERLAG | Published : 2016
Association of liver calcitriol (active vitamin D metabolite) catabolism with osteomalacia during prolonged use of certain drugs was reported in several recent studies. To examine whether the increased calcitriol catabolism could be a potential link between ageing/diabetes mellitus (DM) and bone loss, we studied the dynamic of expression of CYP24, the main calcitriol catabolising enzyme in the liver of rats during ageing and a long-term experimental DM1. DM1 model was induced with intraperitoneally injected streptozotocin (STZ) (55mg/kg). Sprague-Dawley rats were sacrificed 6 and 12 months after the DM1 induction. The immunohistochemical analyses of CYP24 and transforming growth factor β 1 (..View full abstract
Awarded by Ministry of Science, Education and Sports, Republic of Croatia
Awarded by Croatian Science Foundation (HRZZ)
The study was funded by the Ministry of Science, Education and Sports, Republic of Croatia grant no. 216-2160528-0067 and the Croatian Science Foundation (HRZZ) grants nos. 02.05./28 and 8652.