Diabetes mellitus affects activity of calcium/calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia
Milka Jeric, Ana Vuica, Matija Boric, Livia Puljak, Antonia Jelicic Kadic, Ivica Grkovic, Natalija Filipovic
JOURNAL OF CHEMICAL NEUROANATOMY | ELSEVIER SCIENCE BV | Published : 2015
The activity of calcium/calmodulin-dependent protein kinase II alpha (CaMKIIα) may play a critical role in the modulation of nociceptor activity and plasticity of primary sensory trigeminal neurons. The aim of this study was to investigate the immunoreactivity of phosphorylated CaMKIIα (pCaMKIIα) in subpopulations of trigeminal ganglion (TG) neurons in rat models of early diabetes type 1 (dm1) and 2 (dm2). DM1 model was induced with intraperitoneally (i.p.) injected streptozotocin (STZ) (55mg/kg). DM2 rats were fed with the high fat diet (HFD) for 2 weeks and then received 35mg/kg of STZ i.p. Two weeks and 2 months after the STZ-diabetes induction, rats were sacrificed and immunohistochemica..View full abstract
Awarded by Ministry of Science, Education and Sports, Republic of Croatia
Awarded by Croatian Foundation for Science (HRZZ)
This study was funded by the Ministry of Science, Education and Sports, Republic of Croatia (Grant No. 216-2160528-0067) and the Croatian Foundation for Science (HRZZ; Grant No. 02.05./28).